Instructions for a Heatwave is set during the UK’s record-breaking 1976 heatwave and drought. It focuses on an Irish family, led by Gretta and Robert Riordan, who moved to London and raised three children, who have all now left home.. Robert goes out one morning for a newspaper and mysteriously disappears, which is the impetus for a re-grouping of the remaining family members, all of whom are dealing with their own issues and harbouring secrets.

Hamnet is a creative imagining of the story of the death of Shakespeare’s only son. Despite its title, it focuses predominantly on the bard’s wife, here called Agnes (pronounced Ann-yis, and as named in her father’s will) though typically better known as Anne Hathaway. It’s a non-linear narrative with its substantial first section moving back and forth in time between the events leading up to Hamnet’s death from the bubonic plague, and the early days of William and Agnes’ relationship, covering the birth of their three children, first Susanna, whose conception leads to their marriage, and later the twins Judith and Hamnet.

The Marriage Portrait is a heavily fictionalised version of the short life of Lucrezia de' Medici, a sixteenth century member of the renowned aristocratic House of Medici in Italy. As the novel's introductory note explains, she was betrothed to Alfonso II, Duke of Ferrara at very young age, and died fairly soon after their marriage, with persistant (though unproven) rumours alleging that she was poisoned. O'Farrell's interest in the subject was spurred on by seeing a surviving portrait of Lucrezia, attributed to Bronzino, and Robert Browning's poem My Last Duchess, which covers the same subject matter.