Creation Lake is told from the perspective of a spy for hire (and former federal agent) known for the purposes of her current assignment as "Sadie Smith". She is in the process of infiltrating an agrarian commune of eco-leftists in France, known as the Moulinards. In order to do so, she has entered into a serious ‘relationship’ with a filmmaker called Lucien, who is close to the Moulinards' day-to-day leader, Pascal.

The Lacuna focuses on the life of the fictional author Harrison Shepherd, beginning with his childhood in Mexico in the 1930s and taking us through to the 1950s., interacting with significant moments and characters of historical significance along the way. We learn early on that he has kept diaries for much of his life, albeit with some important gaps (one of the lacunae that the title alludes to) and while the narrative is largely told through his diaries, it is mediated by a curatorial presence, the initially mysterious “VB”, and also punctuated by press clippings both real and invented.